Itachi has fought, killed, or escaped from dozens of high ranking and notorious ninja. Fighting someone who possesses an inferior version of sharingan, Itachi could have beat Sasuke if he really wanted to. If Itachi was never sick, it was likely things would have gone the same. The sickness encouraged the two to meet quickly..
Itachi felt it was best to sacrifice himself in order to bestow new powers upon Sasuke while repairing the Uchiha name. There is also shortness of breath, and coughing. Unlike many other forms of vasculitis, such as wegener granulomatosis for example, the upper respiratory tract is usually spared. All the damage is deeper in the lungs. Itachi's case is consistent with this. Other symptoms along the same vein can be seen during his final battle with Sasuke when Itachi grabs his shirt, reacting to what appears to be a heart attack.
Chest pain, myocardial infarction and other signs of cardiac failure are not uncommon effects of this disease, especially considering how it presented. It is also no secret that by the time of his death, Itachi was nearly blind. This, we know, to be a direct result of the mangyeko sharingan. When the mangyeko is used, it clearly puts a tremendous amount of strain on the eye, and the nerves and blood vessels that surround it. Needless to say, it's inflammatory in and of itself.
But it is hasty to assume that Itachi's eye problems are caused by the mangyeko alone. Ocular involvement in MPA is uncommon, but can exist - usually in the form of retinal hemorrhage and scleritis. The bloodshot eyes Itachi sports in his final battle with Sasuke show these symptoms clearly.
And given this, it's no stretch to assume that MPA played a large role in accelerating the damage the mangyeko did to his eyes, hastening his vision loss. Those are the only clues to Itachi's symptoms given outright in canon.
But we can extrapolate others from the way he conducts himself. His low stamina as reported by the databook suggest constitutional symptoms of malaise and fatigue. The peculiar way he rests one hand in his cloak could be an attempt to alleviate painful sensations attributed to peripheral nervous system involvement manifesting as mononeuritis multiplex or myalgia, or simply to support a weakened limb. One could probably even argue his thin stature is evidence of weight loss. There are, of course, come classic manifestations of MPA that cannot be observed in Itachi.
This, however, dos not mean that they can't be rectified. One of the most common ways MPA manifests itself is with renal involvement. We have no evidence that Itachi's kidneys have been damaged by disease. The point I was driving at is that the jutsu that Itachi uses puts an unnatural strain on the body so it starts breaking down. However the assumption I had prior is wrong due to his illness being actually unrelated. Add a comment. Active Oldest Votes. The disease is never named.
This can give a story some realism In other cases, no symptoms are given or the symptoms are very generic, so that it's impossible to determine what disease the character has. Improve this answer. Nullius in Verba Nullius in Verba 1 1 silver badge 4 4 bronze badges. Nikhil Kamath Nikhil Kamath 21 3 3 bronze badges. He kept himself alive through the years with medicine and sheer willpower so that he could live long enough to die by Sasuke's hand. Treveon Treveon 11 1 1 bronze badge.
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